Oxidative Stress


Layton R.H., Payapilli J., Ma T., Murphy T.H., Smirnova N., Langley B.C., Sultana R., Butterfield D.A., Santagata S., Gazaryan I., Bell G.W., and Ratan R.R. (2010) Refining the “peroxide code”: spatial, temporal and quantitative regulation of hydrogen peroxide in astrocytes induces non-cell-autonomous protection of neurons via a novel Nrf-2-independent pathway. PNAS 107(40):17385-90, 2010.

Liu RR, Brown CE, and Murphy TH (2007) Differential regulation of cell proliferation in neurogenic zones in mice lacking cystine transport by xCT. Biochem Biophys Res Commun 364:528-533.

Shih AY, Erb H, and Murphy TH (2007) Dopamine activates Nrf2-regulated neuroprotective pathways in astrocytes and meningeal cells. J Neurochem 101:109-119.

Shih AY, Erb H, Sun X, Toda S, Kalivas PW, and Murphy TH (2006) Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation. J Neurosci 26:10514-10523.

Sun X, Shih AY, Johannssen HC, Erb H, Li P, and Murphy TH (2006) Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface. J Biol Chem 281:17420-17431.

Shih AY, Li P, and Murphy TH (2005a) A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci 25:10321-10335.

Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, Murphy TH (2005b) Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J Biol Chem 280:22925-22936.

Shih AY, Johnson DA, Wong G, Kraft AD, Jiang L, Erb H, Johnson JA, Murphy TH (2003) Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci 23:3394-3406.

Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2:1547-1558.