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Faculty of MedicineMurphy Lab | Department of Psychiatry
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  • Multiscale Imaging with Mesofiber

    Chronic multiscale resolution of mouse brain networks using combined mesoscale cortical imaging and subcortical fiber photometry Daniel Ramandi, Nicholas J. Michelson, Lynn A. Raymond, and Timothy H. Murphy Read More

  • Synthetic Human Form Used to Provide Anonymous Capture for Movement Disorders Assessment

    Towards a Visualizable, De-identified Synthetic Biomarker of Human Movement Disorders J Parkinsons Dis. 2022 Aug 27;1(-1):2085-2096. doi: 10.3233/JPD-223351.  Hao Hu, Dongsheng Xiao, Helge Rhodin, Timothy H Murphy Read More

  • A three-dimensional virtual mouse generates synthetic training data for behavioral analysis

    Nature Methods volume 18, pages378–381(2021) Read More

  • “A big brainstorm is on the horizon in neuroscience”: Globe and Mail

    A Globe and Mail article about the connectome featuring the Murphy lab. Published January 11, 2013. Read More

  • New structural and functional circuits after recovery from stroke

    Cover of J.Neurosci. 29 (6); 11 Feb 2009. Read More

  • Spontaneous cortical activity alternates between motifs defined by regional axonal projections

    Cover of Nat Neurosci. 16 (10); Oct 2013.  Read More

Dr. Timothy H. Murphy

Dr. Timothy H. Murphy

Ph.D. 1989 (Johns Hopkins University Baltimore Maryland)
B.Sc. 1984 (Saint Mary's College Maryland)

Professor | Psychiatry
Associate Member | School for Biomedical Engineering
Member | Djavad Mowafaghian Centre for Brain Health
Lead | Dynamic Brain Circuits in Health and Disease

Publication lists, citation metrics, data and code repositories:

Google Scholar

Web of Science (ResearcherID ISI)

Scopus

ORCID

UBC Brain Circuits Github Code Repo (for our lab and UBC labs)

Open Science Framework (where we share data)

Federated Research Data Repository, large datasets published and pre-publication.

 

General areas of research:

Structure-function of brain circuits in relation to stroke

High-resolution imaging of individual synapses and sensorimotor circuits in live mice to provide insight into mechanisms of initial stroke damage and stroke recovery. We are currently focusing on understanding how sensory and motor circuits compensate after stroke.

CNS synaptic plasticity/physiology mesoscale level

In vivo imaging of synaptic interactions and sensorimotor processing, novel brain mapping procedures using optogenetics.

Automated mouse brain imaging and brain stimulation

We develop models of neurological and psychiatric disease that employ internet-enabled mouse homecages that are used to manipulate and assess brain activity.

Synthetic data used for training behavioral analysis

We have developed a realistic 3-dimensional mouse model capable of generating synthetic behavioral videos to train behavioral classifiers.  We are now beginning projects that take advantage of synthetic human form as a means of quantifying changes in neurological disease.

 

Funding

 


Murphy Lab | Department of Psychiatry | Centre for Brain Health
Faculty of Medicine
Vancouver Campus
4N1 - 2255 Wesbrook Mall
Vancouver , BC Canada V6T 1Z3
Tel 604 822 0705
Email thmurphy@mail.ubc.ca
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