General areas of research:

Structure-function of brain circuits in relation to stroke

High-resolution imaging of individual synapses and sensorimotor circuits in live mice to provide insight into mechanisms of initial stroke damage and stroke recovery. We are currently focusing on understanding how sensory and motor circuits compensate after stroke.

CNS synaptic plasticity/physiology mesoscale level

In vivo imaging of synaptic interactions and sensorimotor processing, novel brain mapping procedures using optogenetics.

Automated mouse brain imaging and brain stimulation

We develop models of neurological and psychiatric disease that employ internet-enabled mouse homecages that are used to manipulate and assess brain activity.

Synthetic data used for training behavioral analysis

We have developed a realistic 3-dimensional mouse model capable of generating synthetic behavioral videos to train behavioral classifiers.  We are now beginning projects that take advantage of synthetic human form as a means of quantifying changes in neurological disease.

Funding