General areas of research:
Structure-function of brain circuits in relation to stroke
High-resolution imaging of individual synapses and sensorimotor circuits in live mice to provide insight
into mechanisms of initial stroke damage and stroke recovery. We are currently focusing on
understanding how sensory and motor circuits compensate after stroke.
CNS synaptic plasticity/physiology mesoscale level
In vivo imaging of synaptic interactions and sensorimotor processing, novel brain mapping procedures
Automated mouse brain imaging and brain stimulation
We develop models of neurological and psychiatric disease that employ internet-enabled mouse homecages
that are used to manipulate and assess brain activity.
Synthetic data used for training behavioral analysis
We have developed a realistic 3-dimensional mouse model capable of generating synthetic behavioral videos
to train behavioral classifiers. We are now beginning projects that take advantage of synthetic human form
as a means of quantifying changes in neurological disease.