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Faculty of MedicineMurphy Lab | Department of Psychiatry
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  • Allen Institute Openscope project

    Federico Bolanos has put forward a successful Openscope project, we are looking for UBC students to help us analyze the data. https://alleninstitute.org/news/mapping-the-brains-visual-world-on-psychedelics-texture-and-time/   Read More

  • Links between cortical mesoscale activity patterns and peripheral nerve activity revealed by Mesotrode.

    Xiao D, Yan Y, Murphy TH 2023 Mesotrode: chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice.   bioaRxiv 2023.02.01.526489; doi: https://doi.org/10.1101/2023.02.01.526489 published Elife via bioaRXiv   Chronic multi-site tetrode recordings to monitor single-neuron activity in multiple subcortical structures (or peripheral sites) while simultaneously imaging the mesoscale activity of the entire […] Read More

  • Neurophotonics cover

    Daniel Ramandi 1, Nicholas J Michelson 1, Lynn A Raymond 1, Timothy H Murphy 1 Neurophotonics doi: 10.1117/1.NPh.10.1.015001. Epub 2023 Jan 21. Read More

  • Multiscale Imaging with Mesofiber

    Chronic multiscale resolution of mouse brain networks using combined mesoscale cortical imaging and subcortical fiber photometry Daniel Ramandi, Nicholas J. Michelson, Lynn A. Raymond, and Timothy H. Murphy Read More

  • Synthetic Human Form Used to Provide Anonymous Capture for Movement Disorders Assessment

    Towards a Visualizable, De-identified Synthetic Biomarker of Human Movement Disorders J Parkinsons Dis. 2022 Aug 27;1(-1):2085-2096. doi: 10.3233/JPD-223351.  Hao Hu, Dongsheng Xiao, Helge Rhodin, Timothy H Murphy Read More

  • A three-dimensional virtual mouse generates synthetic training data for behavioral analysis

    Nature Methods volume 18, pages378–381(2021) Read More

Dr. Timothy H. Murphy

Dr. Timothy H. Murphy

Ph.D. 1989 (Johns Hopkins University Baltimore Maryland)
B.Sc. 1984 (Saint Mary's College Maryland)

Professor | Psychiatry
Associate Member | School for Biomedical Engineering
Member | Djavad Mowafaghian Centre for Brain Health
Lead | Dynamic Brain Circuits in Health and Disease
Lead | Division of Neuroscience and Translational Psychiatry

Publication lists, citation metrics, data and code repositories:

Google Scholar; Web of Science (ResearcherID ISI); 

Scopus; ORCID ; 

UBC Brain Circuits Github Code Repo (for our lab and UBC labs); 

Open Science Framework (where we share data);

Federated Research Data Repository, large datasets published and pre-publication.

 

General areas of research:

Structure-function of brain circuits in relation to stroke

High-resolution imaging of individual synapses and sensorimotor circuits in live mice to provide insight

into mechanisms of initial stroke damage and stroke recovery. We are currently focusing on

understanding how sensory and motor circuits compensate after stroke.

CNS synaptic plasticity/physiology mesoscale level

In vivo imaging of synaptic interactions and sensorimotor processing, novel brain mapping procedures

using optogenetics.

Automated mouse brain imaging and brain stimulation

We develop models of neurological and psychiatric disease that employ internet-enabled mouse homecages

that are used to manipulate and assess brain activity.

Synthetic data used for training behavioral analysis

We have developed a realistic 3-dimensional mouse model capable of generating synthetic behavioral videos

to train behavioral classifiers.  We are now beginning projects that take advantage of synthetic human form

as a means of quantifying changes in neurological disease.

 

Affiliations

 

Funding

 


Murphy Lab | Department of Psychiatry | Centre for Brain Health | Division of Neuroscience and Translational Psychiatry
Faculty of Medicine
Vancouver Campus
2215 Wesbrook Mall Rm 5609
Vancouver , BC Canada V6T 1Z3
Tel 604 822 0705
Email thmurphy@mail.ubc.ca
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